|
Schedule of retinotectal development in different anurans |
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| E. coqui |
D. pictus |
P. pustulosus1 |
X. laevis2 |
|
|
|
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| NeuroD expression (Fig. 1: blue asterisks) |
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| Onset of NeuroD expression in retina |
TS 5 |
? |
? |
NF 23 |
| NeuroD expression downregulated in central retina |
TS 9 |
? |
? |
NF 35–36 |
| Retinotectal differentiation (Fig. 1: blue triangles) |
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| Optic vesicle |
TS 3+ |
GH 18 |
≤GH24 |
NF 21–226 |
| Tectofugal fibers |
TS 5 |
GH 22 |
? |
? |
| Optic vesicle forms cup |
TS 5 |
GH 22 |
≤GH24 |
NF 26–276 |
| Lens forms |
TS 5 |
GH 22 |
≤GH24 |
NF 326 |
| Retinofugal fibers grow out |
TS 6 |
GH 22 |
GH 22 |
NF 29–306 |
| First cells differentiate in retina (PCNA -) |
TS 6 |
GH 23 |
≤GH24 |
NF 28–296,7 |
| Retinofugal fibers in optic chiasm |
TS 7 |
GH 23 |
GH 23 |
NF 326 |
| Retinofugal fibers reach contralateral tectum |
TS 7 |
GH 23 |
? |
NF 35–376 |
| Inner plexiform layer in retina |
TS 9 |
GH 27 |
GH 27 |
NF 35–376 |
| First cells differentiate in tectum (PCNA-) |
TS 9 |
GH 27 |
GH 24 |
NF 41–459,10 |
| Outer plexiform layer in retina |
TS 11 |
GH 30 |
Go 27 |
NF 36–386 |
| Tectal layers 7–9 |
TS 11 |
Go 28 |
Go 27 |
NF 4811 |
| Tectal layer 5 |
TS 13 |
Go 28 |
Go 27 |
NF 4811 |
| Retinal layer of outer segments of photoreceptors |
TS 12 |
Go 28 |
Go 27 |
NF 438 |
| First ipsilateral retinofugal fibers |
TS 9 |
Go 30 |
? |
NF 54–5512 |
| Neuropils in contralateral thalamus |
TS 13 |
Go 30 |
? |
NF 35–3613 |
| Tectal layers 1–43 |
TS 15+6 |
Go 42 |
Go 41 |
NF 519 |
| Retinofugal fibers cover contralat. tectum completely3 |
TS 15+12 |
Go 45 |
? |
NF 668 |
| Retinal growth4 (Fig. 1: red circles) |
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| 40 % |
TS 8 |
Go 28 |
Go 28–41 |
? |
| 60 % |
TS 9 |
Go 29–30 |
Go 28–41 |
? |
| 75 % |
TS 10 |
Go 30–31 |
Go 28–41 |
? |
| 90 % |
TS 11+ |
Go 37 |
Go 28–41 |
? |
| Tectal growth4 (Fig. 1: green circles) |
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| 40 % |
TS 8 |
Go 29/ |
Go 28–41 |
? |
| 60 % |
TS 9 |
Go 29–30 |
Go 28–41 |
? |
| 75 % |
TS11 |
Go 30–31 |
Go 28–41 |
? |
| 90 % |
TS 13- |
Go 31 |
Go 28–41 |
? |
|
1 First stages analyzed: GH 20 (wholemounts), GH 24 (sections) 2 Except for NeuroD expression, data are taken from the literature 3 Out of range of Figure 1 4 Size of cellular layers in percent of reference size; reference size was size of cellular layers at onset of metamorphic climax (stage Go 40) in D. pictus and at hatching (stage TS 15) in E. coqui. For P. pustulosus only stages Go 28 and Go 41 were analyzed and size of cellular layers at stage Go 41 was used as reference 5 TS 15+6 and TS 15+12 refer to stages at 6 and 12 days posthatching in E. coqui 6 [62] 7 [59] 8 [58] 9 [55] 10 [68] 11 Schlosser (unpublished observation) 12 [66] 13 [94] | ||||
Schlosser Frontiers in Zoology 2008 5:9 doi:10.1186/1742-9994-5-9 |
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